Patient Demographics

Age (years)

Serum Creatinine (mg/dL)

Actual Body Weight (kg)

Height (cm)

Biological Sex

Dosing Scenario (Table 2, July 2025 PI)

Initiation 0 → 80 mg BID Initiation 0 → 120 mg BID Escalation 80 → 120 mg BID Escalation 120 → 160 mg BID

160 mg BID is only achievable via escalation from 120 mg — there is no direct 0→160 mg loading column in the July 2025 PI.

Renal Function Method for Dose Selection

GFRᵢ Per PI Table 2 (default) Cockcroft-Gault CrCl Alternate method

Table 2 of the sotalol injection PI (Section 2.3) labels its renal-function axis as GFRᵢ = eGFR/1.73 × BSA — the table this calculator implements is printed in these terms, so GFRᵢ is the default. Section 12.3 (Clinical Pharmacology) reports that comparing Cockcroft-Gault CrCl against MDRD/CKD-EPI-based GFR found "either method leads to the same dosing recommendations," so Cockcroft-Gault is offered as a validated alternate — not because the PI's own table is written in CrCl.

IV Infusion Start Date & Time

Scheduled IV Start (optional)

Enter date and time to generate a complete dose administration schedule with exact timestamps for each dose and QTc monitoring window. Leave blank to view relative timing only.

⚠ Baseline Safety Screen — Required Before Dose Calculation

Per current PI, sotalol IV must not be dosed if ANY of the following contraindications are present. These were previously listed as a static warning only — this calculator now requires them to be entered and will hard-block dose display if a contraindication is present.

Baseline QTc (ms)

Baseline QRS duration (ms)

Required: when QRS is over 100 ms the PI contraindication is assessed on the JT interval (JT > 330 ms) rather than QTc, because a wide QRS inflates QTc and can hide a contraindication.

Serum K⁺ (mEq/L)

Serum Mg²⁺ normalized?

Baseline heart rate (bpm)

Sick sinus syndrome, or 2nd/3rd° AV block WITHOUT a functioning pacemaker?

Congenital or acquired long QT syndrome?

Cardiogenic shock or decompensated heart failure?

Bronchial asthma / active bronchospasm?

Known hypersensitivity to sotalol?

Concomitant Class I or Class III antiarrhythmic?

e.g. quinidine, procainamide, disopyramide, flecainide, propafenone, amiodarone, dofetilide. The PI requires these to be withdrawn before sotalol is dosed — this is a §7.1 sequencing requirement, not a permanent bar to sotalol.

Other (non-antiarrhythmic) QT-prolonging drug?

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GFRᵢ = (eGFR/1.73)×BSA
mL/min · dose selection

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CrCl (Cockcroft-Gault)
mL/min · reference

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eGFR_{CKD-EPI 2021}
mL/min/1.73m² (intermediate value)

Recommended IV Loading Dose · Infuse over 1 hour

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1 hr

Infusion
Duration

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Min. delay to first oral dose
after infusion end

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Oral dosing
interval

📡 QTc Monitoring Protocol (PI Section 2.3)

Monitor QTc every 15 minutes during the 1-hour infusion.
Check QTc at peak (2–4 h post-dose) after the first oral dose in all patients.
Check QTc at peak after the second oral dose in patients with CrCl ≥ 60 mL/min.
If QTc prolongs to >500 ms, or increases ≥20% from baseline on 80 mg initiation → discontinue.
If QTc prolongs to >500 ms on 120 mg initiation → discontinue and consider 80 mg.
Ensure serum K⁺ ≥ 4.0 mEq/L and Mg²⁺ normalized before and throughout therapy.

References

Sotalol Hydrochloride Injection (Sotalol IV) Prescribing Information. NDA 022306. AltaThera Pharmaceuticals LLC, 2025 revision — dosing tier table (Table 2) and QTc monitoring protocol (Section 2.3).
Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41. (CrCl equation — used for dose-tier selection when Cockcroft-Gault is selected as the alternate method)
Devine BJ. Gentamicin therapy. Drug Intell Clin Pharm. 1974;8:650-655. (Ideal body weight formula, used in the Cockcroft-Gault alternate method only)
Inker LA, Eneanya ND, Coresh J, et al. New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race. N Engl J Med. 2021;385:1737-1749. (CKD-EPI 2021 eGFR — the basis for GFRᵢ, the default dose-tier method per PI Table 2)
Du Bois D, Du Bois EF. A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med. 1916;17:863-871. (BSA formula — used to de-index eGFR into GFRᵢ, the default dose-tier method)

Sotalol IV Loading Calculator