SepsisRx is intended solely for use by licensed healthcare professionals as a verification support tool. It does not replace independent clinical judgment, current institutional sepsis protocol, or timely escalation to critical care.
SepsisRx
NEWS2 and qSOFA + Sepsis-3 screening, adult SOFA, the Phoenix Sepsis Score (2024) and pSOFA for pediatric sepsis, and Surviving Sepsis Campaign 2026 early management timing for verification support.
NEWS2 — National Early Warning Score 2
The 2026 SSC guideline recommends NEWS, NEWS2, MEWS, or SIRS over qSOFA for hospital sepsis screening. Among these, NEWS2 had the best absolute test performance in the large cohort study the guideline cites (sensitivity 73.1%, AUC 0.77, vs. qSOFA's sensitivity of 23.1%) — shown here as the best-performing option, not a formal single guideline endorsement (the panel recommended the class of tools, not NEWS2 specifically, given its lower specificity and high false-positive rate). NEWS2 is a general deterioration score, not sepsis-specific — a positive score should prompt full clinical assessment, not an automatic sepsis diagnosis.
Enter values and click Calculate.
qSOFA — Bedside Sepsis Screen
Three criteria immediately available at the bedside, intended to prompt further organ-dysfunction assessment (SOFA) in a patient with suspected infection — qSOFA is a screening prompt, not itself a diagnostic criterion for sepsis.
2026 SSC guidance: do not use qSOFA alone as a hospital screening toolThe 2026 Surviving Sepsis Campaign guideline gives a strong recommendation (moderate certainty) for using NEWS, NEWS2, MEWS, or SIRS over qSOFA as a single tool to screen acutely ill hospitalized patients for sepsis — a large cohort study (n>221,000) found qSOFA had the lowest sensitivity of these tools. qSOFA is retained below for its original Sepsis-3 role (a bedside prompt once infection is already suspected/confirmed, and an input to the Sepsis-3 septic shock definition) — use the NEWS2 card above as your primary screening tool instead.
Enter values and click Calculate.
Sepsis-3 Diagnostic Criteria
The Third International Consensus Definitions (Sepsis-3, 2016) removed SIRS and "severe sepsis" from the diagnostic framework. Use this alongside the SOFA tab.
Enter values and click Evaluate.
SOFA Score — Adult
Six organ systems, 0-4 points each (range 0-24). Enter the worst value for each system over the assessment period. Table reproduced from Lambden et al. 2019 (modified from the original Vincent et al. 1996 SOFA score).
Respiratory — pts
Coagulation — pts
Liver — pts
Cardiovascular — pts
Central Nervous System — pts
Renal — pts
Enter values and click Calculate.
Vasopressor Dosing Reference — Septic Shock
Typical ICU dosing ranges. Norepinephrine is first-line per the Surviving Sepsis Campaign; dopamine is an alternative only if norepinephrine is unavailable or arrhythmia risk is low. All require central access for anything beyond brief peripheral bridging.
Agent
Typical Dosing
Notes
Norepinephrine
~0.01–3 mcg/kg/min (weight-based ICU convention — the FDA label itself predates weight-based dosing and is expressed in mcg/min)
First-line (SSC strong recommendation). Central line preferred.
Vasopressin
SSC/trial convention: fixed ~0.03 units/min (range 0.01–0.04), typically NOT titrated to effect — added as a second agent, usually once norepinephrine reaches roughly 0.25–0.5 mcg/kg/min, rather than escalating norepinephrine further.
See discrepancy note below — the current FDA label permits a titratable range that differs from this fixed-dose trial convention.
Epinephrine
~0.01–0.5 mcg/kg/min
Added or substituted if MAP not maintained on norepinephrine ± vasopressin.
Phenylephrine
~0.4–9.1 mcg/kg/min (or ~100–180 mcg/min)
Pure alpha-1 agonist, no chronotropy — reasonable when tachyarrhythmia limits norepinephrine.
Dopamine
~2–20 mcg/kg/min
Alternative to norepinephrine only if unavailable or low arrhythmia risk (SSC).
Angiotensin II (Giapreza)
FDA label: start 20 ng/kg/min, titrate q5min by up to 15 ng/kg/min; max 80 ng/kg/min (first 3h) / 40 ng/kg/min maintenance; minimum effective dose 1.25 ng/kg/min
Catecholamine-refractory adjunct (ATHOS-3 trial). Central line recommended. Thromboembolic risk signal in ATHOS-3 (13% vs. 5% placebo) — consider VTE prophylaxis.
Vasopressin dosing discrepancy — disclosed, not resolvedThe current FDA Vasostrict label permits titration for septic shock (start 0.01 units/min, titrate by 0.005 units/min every 10–15 min, max 0.07 units/min). This differs from the fixed low-dose convention (~0.03 units/min, not titrated) used in the VASST trial (Russell et al., N Engl J Med 2008) and reflected in Surviving Sepsis Campaign guidance. Both are shown here rather than silently picking one — follow your institutional protocol.
Rate ↔ Dose Converter
Pure unit conversion (not a clinical recommendation) — for translating a pump rate to a weight-based dose, or a target dose to a pump rate, using whatever bag concentration your institution has mixed. Useful when verifying an order written in mL/hr against a mcg/kg/min target, or vice versa.
Enter bag concentration, weight, and rate, then calculate.
Enter bag concentration, weight, and target dose, then calculate.
Vasopressin (units/min — not weight-based)
Enter bag concentration and either a rate or a target dose, then calculate.
MAP Target & Escalation Ladder
Sequencing per the 2021 Surviving Sepsis Campaign guideline (2026 update's vasopressor/steroid section was not independently re-verified for this tool — confirm against the current guideline directly before relying on the steroid-timing threshold below).
MAP targetInitial target ~65 mmHg. Consider an individualized higher target (~80–85 mmHg) in patients with chronic hypertension (SEPSISPAM trial, Asfar et al., N Engl J Med 2014) — this reduced AKI/renal replacement need but increased atrial fibrillation risk, so it is a trade-off, not a universal upgrade.
Escalation sequence(1) Norepinephrine first-line. (2) Add vasopressin, typically once norepinephrine reaches roughly 0.25–0.5 mcg/kg/min, instead of escalating norepinephrine further. (3) Add or substitute epinephrine if MAP is still not maintained on norepinephrine ± vasopressin. (4) Angiotensin II as a catecholamine-refractory adjunct (see reference table).
Corticosteroids in septic shockSSC 2021 suggests IV hydrocortisone (200 mg/day — 50 mg IV q6h or continuous infusion) when norepinephrine or epinephrine ≥0.25 mcg/kg/min for ≥4 hours has not restored hemodynamic stability. Whether fludrocortisone co-administration is specifically endorsed, and whether the 2026 SSC update revised this threshold, were not independently confirmed against the primary guideline text in this tool's development — verify directly before applying.
Norepinephrine-Equivalent Dose (NED) Calculator
NED is not a standardized formula — multiple published conversion formulas exist, and they diverge substantially, especially for angiotensin II. This calculator uses the coefficients from Goradia S et al. (scoping review), J Crit Care 2021;61:233-240 — one of the most-cited sources, not the only one. A competing formula (Kotani Y et al., Crit Care 2023;27:29) uses a materially different angiotensin II coefficient. Because of that divergence, angiotensin II is deliberately excluded from the total below rather than combined in with false precision — enter it for reference only.
The current, internationally-endorsed (Society of Critical Care Medicine) definition of pediatric sepsis and septic shock, derived from >3 million pediatric encounters across 10 countries — analogous to Sepsis-3 for adults, and now the recommended definition rather than extrapolating adult Sepsis-3/SOFA criteria to children (see the pSOFA card below, now secondary). Four subscores (respiratory 0-3, cardiovascular 0-6, coagulation 0-2, neurologic 0-2); total range 0-13.
Respiratory — pts
Cardiovascular — pts
Coagulation — pts (max 2, 1 pt each)
Neurologic — pts
Enter values and click Calculate.
pSOFA — Pediatric Sequential Organ Failure Assessment
Adapts the cardiovascular and renal subscores to age-banded cutoffs (from PELOD-2) and adds an SpO₂/FiO₂ alternative for respiratory. Coagulation, hepatic, and neurologic subscores are unchanged from the adult SOFA score. Table reproduced from Matics & Sanchez-Pinto, JAMA Pediatr. 2017.
Secondary tool as of 2024pSOFA was developed to test whether adult Sepsis-3 organ-dysfunction scoring extrapolates to children — it was never itself a consensus pediatric sepsis definition. The Phoenix Sepsis Score above is now that consensus definition; use pSOFA for general organ-dysfunction trending/severity, not as your primary tool for diagnosing pediatric sepsis or septic shock.
Respiratory — pts
Coagulation — pts
Hepatic — pts
Cardiovascular — pts
Neurologic — pts
Renal — pts
Enter values and click Calculate.
⚠ Surviving Sepsis Campaign 2026 — Early Management Timing
The 2026 SSC guideline retired the single "Hour-1 Bundle" framing in favor of differentiated timing per element, based on whether shock/hypoperfusion is present and how likely sepsis is (Table 3 terminology: definite / probable / possible / unlikely). Set the inputs below, then track elapsed time against each element's actual target.
Set the inputs above to see element-specific targets and an on-track / overdue flag for each.
1. Obtain blood cultures no fixed target — ASAP
Collect as soon as possible and ideally before antimicrobial therapy — but do not delay antibiotics for cultures if collection isn't rapidly achievable (2026 SSC Statement 7, strong recommendation).
2. Measure blood lactate no fixed target
Suggested for possible, probable, or definite sepsis/septic shock (Statement 8, conditional recommendation). The 2026 guideline does not itself specify a remeasurement interval; individualize fluid administration to lactate trend/decrement rather than treating a single normalized value as the endpoint.
3. Rapid infectious vs. noninfectious assessment ≤ 3 hr
For possible sepsis without shock only (Statement 19/20): history, exam, and testing for both infectious and noninfectious causes, ideally completed within 3 hours, to decide whether antibiotics are warranted. If the likelihood is definite/probable, or shock is present, skip straight to antibiotics.
4. Administer broad-spectrum antibiotics — pts
Target time depends on shock status and sepsis likelihood — see badge above.
5. Begin ≥ 30 mL/kg IV crystalloid ≤ 3 hr
SSC 2026: "For adults with sepsis-induced hypoperfusion or septic shock, we suggest administering at least 30 mL/kg of IV crystalloid in the first 3 hr" — the target is 3 hours, not 1 hour. Note this is a conditional recommendation on low certainty of evidence, and 30 mL/kg is a floor rather than a prescription: the guideline's own remark states that "consideration should be given to individual patient characteristics and context when selecting initial fluid volume", with frequent ongoing reassessment to avoid the harms of both under- and over-resuscitation. Use actual body weight, or adjusted/ideal body weight if BMI > 30 kg/m². Not indicated as a fixed-volume requirement in patients without hypoperfusion.
6. Start vasopressors if hypotension persists MAP target —
Give the initial crystalloid bolus first, then start vasopressors (norepinephrine first-line) if hypotension persists — immediate concurrent administration with fluids may be warranted case-by-case in unstable shock (Statement 11). Start peripherally rather than delaying for central access (Statement 12). MAP target shown reflects age.
7. Source control, if a specific source requires it ≤ 6 hr
If sepsis/septic shock has a specific anatomical diagnosis or source requiring intervention (abscess drainage, device removal, etc.), pursue source control as soon as medically/logistically practical, ideally within 6 hours (Statement 24). Rapid evaluation for a source requiring control is itself a good-practice statement (Statement 23) regardless of timing.
References
Prescott HC, Antonelli M, Alhazzani W, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026. Crit Care Med. 2026;54(4):725-812. doi:10.1097/CCM.0000000000007075. (Primary source, read directly in full text — the current SSC guideline. Source of: the strong recommendation against qSOFA as a sole hospital screening tool in favor of NEWS/NEWS2/MEWS/SIRS [Statement 4]; the retirement of the "Hour-1 Bundle" framing in favor of differentiated per-element timing [Fig. 2, Statements 7-24]; the 3-hour — not 1-hour — target for ≥30 mL/kg crystalloid [Statement 10]; the 1-hour antibiotic target for septic shock or probable/definite sepsis and 3-hour target for possible sepsis without shock [Statements 16-20]; peripheral vasopressor initiation without delay for central access [Statement 12]; MAP targets of 65 mmHg, or 60-65 mmHg if age ≥ 65 [Statements 13-14]; and the 6-hour source-control target [Statement 24]. All of these are used directly in the Early Management Timing tab above.)
Lambden S, Laterre PF, Levy MM, Francois B. The SOFA score—development, utility and challenges of accurate assessment in clinical trials. Crit Care. 2019;23(1):374. Open access (PMC6880479). (Table 1 — adult SOFA scoring criteria, "modified from Vincent et al." — reproduced directly in the SOFA tab above)
Vincent JL, Moreno R, Takala J, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Intensive Care Med. 1996;22(7):707-710. PMID 8844239. (Original SOFA score; paywalled with no free full text found in this environment — confirmed via the open-access Lambden et al. 2019 reproduction above rather than read directly)
Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-810. PMID 26903338. (Sepsis-3 definitions; paywalled, not read directly)
Shankar-Hari M, Phillips GS, Levy ML, et al. Developing a New Definition and Assessing New Clinical Criteria for Septic Shock. JAMA. 2016;315(8):775-787. PMID 26903336. (Septic shock definition — persistent hypotension requiring vasopressors to maintain MAP ≥ 65 mmHg plus lactate > 2 mmol/L despite adequate fluid resuscitation; paywalled, not read directly)
Seymour CW, Liu VX, Iwashyna TJ, et al. Assessment of Clinical Criteria for Sepsis (Sepsis-3): qSOFA derivation study. JAMA. 2016;315(8):762-774. PMID 26903335. (qSOFA derivation; paywalled, not read directly)
Imamura M, Duggan SN, Vadiveloo T, et al. Clinical utility of biomarkers for outcomes prediction in adults with suspected sepsis presenting to the emergency department. NIHR Journals Library / NCBI Bookshelf. 2026. NBK621512. Open access. (Independent, freely accessible confirmation of the exact qSOFA criteria — SBP ≤ 100 mmHg, GCS < 15, respiratory rate ≥ 22/min, qSOFA ≥ 2 — and of the Sepsis-3 septic shock definition, both cross-checked against this chapter since the primary Singer/Shankar-Hari/Seymour papers above are paywalled)
Royal College of Physicians. National Early Warning Score (NEWS) 2: Standardising the assessment of acute-illness severity in the NHS. Updated report. London: RCP, 2017. (Original source of the NEWS2 chart used in the NEWS2 card above; the RCP's own site returned a 403 in this environment and could not be fetched directly)
Nafea OE, Ibrahim F, Abdelhamid WG. The National Early Warning Score 2 versus the New-Poisoning Mortality Score System for Predicting Clinical Outcomes After Acute Aluminum Phosphide Poisoning. Toxicol Res (Camb). 2025;14(1):tfae230. Open access (PMC11707535). (Independent, open-access reproduction of the full official NEWS2 table — all 7 parameters with exact point cutoffs, including the Scale 2 SpO₂ criteria for chronic hypercapnic respiratory failure — used to build and verify the NEWS2 card above since the RCP's own chart was unreachable. One cell, the Scale-2 SpO₂-on-oxygen 88-92% band, was inferred rather than directly quoted to fill a gap in the extracted table — see the code comment in this tool for detail)
Matics TJ, Sanchez-Pinto LN. Adaptation and Validation of a Pediatric Sequential Organ Failure Assessment Score and Evaluation of the Sepsis-3 Definitions in Critically Ill Children. JAMA Pediatr. 2017;171(10):e172352. NIH public access full text (PMC6583375). (Table 1 — pSOFA age-banded cardiovascular and renal cutoffs, and the SpO₂/FiO₂ respiratory alternative — reproduced directly in the pSOFA tab above; pSOFA is now the secondary/legacy pediatric tool in this app, superseded as the primary pediatric sepsis definition by the Phoenix Sepsis Score below. The 2026 SSC guideline above is adults-only and does not address pSOFA or Phoenix.)
Sanchez-Pinto LN, Bennett TD, DeWitt PE, et al. Development and Validation of the Phoenix Criteria for Pediatric Sepsis and Septic Shock. JAMA. 2024;331(8):675-686. PMID 38245897. Free full text via PMC10900964 (publisher disables full-text XML download; HTML retrieved via automated tooling rather than manually read). (Source of the Phoenix Sepsis Score table used in the Phoenix tab above — respiratory 0-3, cardiovascular 0-6 [vasoactive medications + lactate + age-banded MAP], coagulation 0-2, neurologic 0-2; sepsis = infection + score ≥2; septic shock = sepsis + ≥1 cardiovascular point)
Schlapbach LJ, Watson RS, Sorce LR, et al. International Consensus Criteria for Pediatric Sepsis and Septic Shock. JAMA. 2024;331(8):665-674. PMID 38245889. Free full text via PMC10900966 (same publisher restriction as above). (Companion consensus paper; used to cross-check the cardiovascular subscore structure — each of vasoactive medications/lactate/MAP scored 0-2 and summed — extracted independently from this paper and the Sanchez-Pinto paper above, with matching results)
Goradia S, Sardaneh AA, Narayan SW, Penm J, Patanwala AE. Vasopressor dose equivalence: A scoping review and suggested formula. J Crit Care. 2021;61:233-240. PMID 33220576. (Source of the Norepinephrine-Equivalent Dose formula used in the Vasopressors/NED tab: NED = norepinephrine + epinephrine + phenylephrine/10 + dopamine/100 + vasopressin×2.5, all mcg/kg/min except vasopressin in units/min. One of several published, non-standardized formulas — disclosed in-app rather than presented as the single correct answer)
Kotani Y, Di Gioia A, Landoni G, Belletti A, Khanna AK. An updated "norepinephrine equivalent" score in intensive care as a marker of shock severity. Crit Care. 2023;27:29. Open access (PMC9854213). (Competing NED formula — its angiotensin II coefficient diverges by orders of magnitude from Goradia 2021 depending on unit convention, which is why this tool excludes angiotensin II from its calculated NED total rather than combining formulas)
Russell JA, Walley KR, Singer J, et al. Vasopressin versus norepinephrine infusion in patients with septic shock (VASST). N Engl J Med. 2008;358(9):877-887. (Source of the fixed, non-titrated ~0.03 units/min vasopressin convention used in the reference table above, contrasted against the current FDA label's titratable range — paywalled, not read directly)
FDA prescribing information: Vasostrict (vasopressin injection), DailyMed. (Current label permits titration for septic shock — start 0.01 units/min, titrate by 0.005 units/min every 10-15 min, max 0.07 units/min — a genuine discrepancy with the VASST/SSC fixed-dose convention above, disclosed rather than resolved)
Khanna A, English SW, Wang XS, et al. Angiotensin II for the Treatment of Vasodilatory Shock (ATHOS-3). N Engl J Med. 2017;377(5):419-430. (Trial underlying the angiotensin II dosing/positioning in the reference table above — catecholamine-refractory adjunct, thromboembolic risk signal 13% vs. 5% placebo)
FDA prescribing information: Giapreza (angiotensin II), DailyMed. (Source of the angiotensin II dosing figures in the reference table: start 20 ng/kg/min, titrate q5min by up to 15 ng/kg/min, max 80/40 ng/kg/min, minimum effective 1.25 ng/kg/min)
Asfar P, Meziani F, Hamel JF, et al. High versus low blood-pressure target in patients with septic shock (SEPSISPAM). N Engl J Med. 2014;370(17):1583-1593. (Source of the individualized-higher-MAP-target-in-chronic-hypertension note in the MAP Target & Escalation Ladder card — reduced AKI/renal replacement need, increased atrial fibrillation risk; paywalled, not read directly)
Historical/superseded — retained for context only, no longer used as this tool's source for current timing targets: Bullock B, Benham R. Bacterial Sepsis. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; updated 2023 May 21. NBK537054. Open access. Levy MM, Evans LE, Rhodes A. The Surviving Sepsis Campaign Bundle: 2018 Update. Crit Care Med. 2018;46(6):997-1000. Evans L, Rhodes A, Alhazzani W, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. Crit Care Med. 2021;49(11):e1063-e1143. Abdelaziz H, Thibeault P, Laporte Maher M, et al. Evaluation of Sepsis Management in a Regional Community Hospital. J Glob Infect Dis. 2026;18(1):19-26 (PMC13061154). Ekingen E, Ucdal M. Agentic GPT-5.0 system outperforms standard large language models and human experts in critical care clinical decision-making. BMC Med Inform Decis Mak. 2026;26:504 (PMC13321615). (These five sources were used in the original build of this tool's Hour-1 Bundle tab, before direct access to the 2026 SSC guideline was available — see revision note below. The 30 mL/kg-in-1-hour and single-bundle framing they supported has been superseded.)
Sourcing note: the 2026 SSC guideline (first reference above) was supplied directly and read in full text, and is now this tool's primary source for all early-management timing content and the qSOFA screening caveat. The original 1996 SOFA paper and the three 2016 Sepsis-3 JAMA papers remain paywalled in this environment (Wolters Kluwer/Crit Care Med, JAMA/Intensive Care Med) and were not read directly — those numeric thresholds were instead independently cross-checked against freely accessible reproductions: an open-access Critical Care review (Lambden 2019) for the SOFA table, a 2026 NIHR Journals Library chapter on NCBI Bookshelf for qSOFA/Sepsis-3 definitions, and the NIH-public-access full text of the pSOFA paper itself (Matics & Sanchez-Pinto 2017) for the pediatric table. If your institution has direct access to these three primary papers, independent verification is still worthwhile, particularly before this tool is used to drive automated alerts or order sets.
Revision note (2026 SSC guideline): this tool's Early Management Timing tab was originally built as a "Hour-1 Bundle" (2018 Levy et al. framing), sourced only to a secondary StatPearls chapter and two open-access papers because the current SSC guideline itself was paywalled and unreachable in this environment. When the actual 2026 SSC guideline PDF was supplied directly, two errors were found and fixed: (1) the ≥30 mL/kg crystalloid target is 3 hours, not 1 hour — the original build had incorrectly folded it into a single 1-hour bundle; (2) the current guideline no longer uses "Hour-1 Bundle" branding at all, and gives a strong recommendation against using qSOFA alone as a hospital sepsis screening tool (in favor of NEWS/NEWS2/MEWS/SIRS) — a caveat the qSOFA tab did not originally carry. The tab was restructured to reflect the guideline's actual differentiated timing (shock status × sepsis likelihood, per Fig. 2) rather than a single deadline for every element.
Disclosure (Vasopressors/NED tab): the corticosteroid-initiation threshold shown (norepinephrine/epinephrine ≥0.25 mcg/kg/min for ≥4 hours) is sourced to the 2021 SSC guideline via secondary corroboration (SCCM site copy, AAFP/UIC summaries) — the 2021 and 2026 SSC primary texts both returned access errors for this specific section during this tool's development, and whether the 2026 update revised this threshold or added fludrocortisone was not independently confirmed, even though the 2026 guideline was read directly in full text for the Early Management Timing tab above (that reading did not happen to cover this specific vasopressor/steroid section). Verify directly against the current guideline before treating this threshold as current. The NED formula itself is disclosed in-app as one of several non-standardized options — see the Goradia and Kotani/Khanna references above.
Revision note (Phoenix Sepsis Score added): the original pediatric tab offered only pSOFA, extrapolating adult Sepsis-3/SOFA logic to children. A subsequent evidence audit found that the Phoenix Sepsis Score (2024), derived and validated on over 3 million pediatric encounters across 10 countries and endorsed by the Society of Critical Care Medicine, is now the current international consensus definition of pediatric sepsis and septic shock — pSOFA itself was never a consensus sepsis definition, only a tool built to test whether adult organ-dysfunction scoring extrapolates to children. The Phoenix Sepsis Score was added as the primary pediatric tool, with pSOFA retained beneath it as a secondary organ-dysfunction reference. Both Phoenix papers are JAMA-published and paywalled; the publisher disables full-text XML download even through the free PMC copy, so the scoring table above was extracted via automated retrieval of the PMC HTML rather than manually read line-by-line, and cross-checked for internal consistency across both companion papers (Sanchez-Pinto and Schlapbach) before being coded. If your institution has direct JAMA access, independent verification against the original Table 2 is recommended before relying on this tab for high-stakes decisions.
Clinical Disclaimer: SepsisRx is a reference and verification aid for licensed healthcare professionals. It is not autonomous clinical software and does not replace clinical judgment, patient-specific assessment, institutional sepsis protocol, or timely escalation to critical care / rapid response.